Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease
نویسندگان
چکیده
منابع مشابه
Application of extracellular vesicles in the treatment of inflammatory bowel disease
Introduction: Inflammatory bowel disease(IBD) is caused by genetic, environmental, microbial and immune factors. IBD has two primary forms: Ulcerative colitis and Crohn´s disease. The incidence of IBD has significantly increased over the last few decades. Given that patients have poor response to drug treatments or are resistant to drug therapies, new therapies are needed for gastrointestinal i...
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Despite being a mainstay of inflammatory bowel disease (IBD) therapy, glucocorticoids (GCs) still carry significant risks with respect to unwanted side effects. Alternative drugs with a more favorable risk/benefit ratio than common GCs are thus highly desirable for the management of IBD. New and supposedly selective glucocorticoid receptor (GR) agonists (SEGRAs), with dissociated properties, ha...
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Ulcerative colitis (UC), characterized by inflammation, oxidative stress, and increased intestinal epithelial cell apoptosis, is an immunologically mediated chronic intestinal disorder. The present study was aimed at investigating the protective effects of alpha-lipoic acid (ALA) against trinitrobenzene sulfonic acid (TNBS)-induced UC and the underlying mechanism. ALA of 80 mg/kg bw/day was adm...
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Objective(s):In the present study, we evaluated immunological and immunomodulatory properties of royal jelly (RJ) in 2,4,6 trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. Materials and Methods: Eighteen adult female Wistar albino rats were divided into three groups of six animals each: a control group that received only saline solution, a TNBS-induced colitis group, and a TNBS-co...
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Inflammatory bowel diseases (IBD) including most important forms; Crohn’s disease (CD) and ulcerative colitis (UC); are chronic diseases affecting the gastrointestinal tract with unclear etiology and pathology. The role of gut microbiota has recently been considered as major a factor, since altered microbiome or "dysbiosis" is a key player in the protracted course of inflammation in IBD. Howeve...
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ژورنال
عنوان ژورنال: Journal of Dairy Science
سال: 2018
ISSN: 0022-0302
DOI: 10.3168/jds.2018-15014